Skip to main content

Detection of bio-markers over the past decade"




 Detection of bio-markers over the past decade"
As we are fully aware of the fact that the development of the new bio-markers is of great significance in treating and preventing the diseases or the complex toxins outbreaks in the body, so scientist and researchers are always eager to find new bio-markers to prevent the onslaught of the diseases.
First of all lets us know that what is a bio-marker? A bio-marker can be termed as characteristic that can play a very vital role in the reflection of the intensity of a disease in the body. It can also be used as a detector to indicate a disease in the body; it can be assessed by a particular antibody produced in response to that disease. Moreover, they also make us enable to initiate a therapy which can act only on the target site in the body to prevent the loss of the healthy cells and tissues in the body. Bio-markers can be classified as disease related and drug related bio-markers. Disease related bio-markers help us to have knowledge about the development and the progression of the disease, and helps us to learn about the mechanism of the development of the disease in the body, whereas drug related bio-markers help us to find about the efficacy of the drug in a particular against a particular disease.Biomarkers Poised for Breakout Moment
            Although still a lot of work has to be done in this field, however major advancements have been made for the progress in the quantitative detection of the bio-markers over the past decade. In the past bio-markers were only considered as the physiological indicator like high blood pressure was considered as an indicator of the hypertension, but the scenario is different now as the term bio-marker has a broad aspect to consider in the era. Some of the new bio-markers being used over the past decade are in the next paragraphs.
 For example the research of bio-markers has revolutionized the treatment of cancer patients like in case of EGFR associated cancers in the patients in whom the tumor is involved in the expression of the mutated KRAS gene OR KRAS protein, which constitutes the pathway for the EGFR signaling. This continues signaling is a bio-marker of the fact that there is a continuous and proliferated growth of the cancer cells. These bio-markers have the ability to detect the cancer at its early stage to prevent any further damage and enables physicians to start a definitive therapy against the cancer patients. One of the most famous bio-marker over the past few years is CTC (circulating tumor cell), present in the bodies of the cancer patients. In recent times it is almost possible to develop a new anti cancer drug as it is used to measure the response of the cancer to a particular drug.
            Besides cancer a number of diseases are usually symptom less in their early phases like in case of Alzheimer’s disease, diabetes mellitus, rheumatoid arthritis etc. in this case bio-markers are playing a very significant role as they detect the disease in its early stage so make it possible to treat with its proceeding towards an alarming condition. Likewise, bio-marker like C-reactive protein is a bio-marker which is released by the artherosclertic plaques in the arteries helps us to understand the pathophysiology of the cardiovascular diseases like in the case of artherosclerotic plaques in the arteries. Aldosterone a hormone produced by the adrenal cortex also acts as a biomarker to check the pharmacological effect of the drugs such as 5-HT4 receptor agonist in the body.
Although advancements have been made in the past decade, however development of new biomarkers has become a challenge for the researchers, like for the disease like chronic obstructive pulmonary disease there is still a need of the bio-markers.

Comments

Post a Comment

Popular posts from this blog

Obesity Linked with food in American Schools

Obesity Linked with food in American Schools By Mahvisha Kanwal What’s the issue?                               In USA, elementary and primary schools takes the responsibility of providing a free lunch facility to the students. Although all of the schools have maintained the quality of food, but according to a recent study, almost one third of all the children and youth are considered as over-weight. The basic cause of this issue is that, the nutritional value of food is not being kept in mind by the school community. Another issue of increasing rate of obesity is that the schools food department attract the children by making yummy fast food which is for sure not healthy for the children. That’s why children like to eat food from the school cafe rather to bring from home. According to WhatsForLunchNYC.com , a New York City-based ...
Post a Comment
Read more

ANATOMY OF NEUROTRANSMITTERS

Anatomy of neurotransmitters An understanding of the synaptic transmission is of great importance in understanding the basic principle of chemical signaling between the neurons. This chemical process of interaction or signaling between the neurons occurs at the end of the axon, in a structure called synapse. Synapse: As neurons form a network, so they have to be interconnected for the purpose of transmission of nerve impulse from one neuron to the other. But, unlike other cells there is a lack of a cellular continuity between two neurons, as they have a space between them called as the synapse. The mechanism of chemical signaling involves the release of a chemical, called a neurotransmitter from a presynaptic neuron, which further binds to the receptors which are located in the postsynaptic neuron. These neurotransmitters then act on their particular receptors and produce a particular response. Neurotransmitters: Neurotransmitters are defined as endogenous chemicals i...
Post a Comment
Read more

ANATOMY OF THE NERVES

Anatomy of   the nerves Cells of the nervous system: There are basically two types of cells in the nervous system, named as Glial cells and the neurons or nerve cells. The main function of the Glial cells is as follows: 1.       To nourish neurons. 2.       To provide a structural support to the neurons 3.       They help in the removal of waste products from the neurons. 4.       Insulating neurons are another function of the Glial cells. Neurons, the other cells play a significant role in the communication along the nervous system and hence can be regarded as the communicators of the Nervous system. Neuron, the messenger in the body receives information, then process it according to the nature of the information and finally pass it along. They not only communicate with one another, but also with the sensory organs and the muscles in the body. (1) Physical ...
Post a Comment
Read more