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healthconcerns: ANTIBODY DIRECTED ENZYME PRODRUG THERAPY

healthconcerns: ANTIBODY DIRECTED ENZYME PRODRUG THERAPY: Antibody Directed Enzyme Prodrug Therapy (ADEPT) Ehealthconcerns has brought again a new sensational technology for treating the ca...

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ANTI-MULLERIAN HORMONE AND FERTILITY

ANTI-MULLERIAN HORMONE AND FERTILITY Initially Anti-Mullerian hormone was only considered in its involvement in the sexual differentiation and Mullerian regression in the males, but now it serves as a bio-marker for the ovarian reserve. It expresses itself in the small antral follicles. It can predict the condition of the patients with assisted reproductive therapy and it is also important in the patients with the polycystic ovary. The following points elaborates the role of AMH in the fertility Anti-Mullerian hormone and its effect on fertility and infertility. ·          Anti – Mullerian hormone is a protein in its composition and is encoded by the help of the AMH gene. ·          It is produced by the granulose cells which are present in the ovarian cells. ·          It has a molecular weight of 140 KDa. ·          AMH which is also known as Mullerian-inhibiting substance is a member of the super family named as transforming growth factor-beta(TGF-β). This fa
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6-MERCAPTOPURINE

Healthconcerns “Articles on cancer” is going to add a complete pharmacology and the medicinal chemistry of the Anti-cancer drugs. So here is the first one as “6-MERCAPTOPURINE” 6-Mercaptopurine Chemical structure Chemically 6-Mercaptopurine is analog of adenine and hypoxanthine                                                  Mechanism of action 6-Mercaptupurine is converted to   6- Mercaptopurine nucleosides leading to De novo inhibition of purine nucleotide synthesis. ¨       6-Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine/guanine phosphoribosyltransferase  and itself converted to thioinosinic acid                                                                      Inosinic acid (I) MP                                                                                  Thioinosinic acid (I MP)   ¨       TIMP inhibits several reactions involving inosinic mono phosphate (IMP) including its convers
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