healthconcerns: ANTIBODY DIRECTED ENZYME PRODRUG THERAPY:   Antibody Directed Enzyme Prodrug Therapy (ADEPT)     Ehealthconcerns has brought again a new sensational technology for treating the ca...
     Healthconcerns “Articles on cancer” is going to add a complete pharmacology and the medicinal chemistry of the Anti-cancer drugs. So here is the first one as “6-MERCAPTOPURINE”       6-Mercaptopurine          Chemical structure       Chemically 6-Mercaptopurine is analog of adenine and hypoxanthine                                                         Mechanism of action     6-Mercaptupurine is converted to   6- Mercaptopurine nucleosides leading to De novo  inhibition of purine nucleotide synthesis.   ¨       6-Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine/guanine phosphoribosyltransferase  and itself converted to thioinosinic acid                                             ...
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