Medical affliction of the cartoon world

6-MERCAPTOPURINE

Healthconcerns “Articles on cancer” is going to add a complete pharmacology and the medicinal chemistry of the Anti-cancer drugs. So here is the first one as “6-MERCAPTOPURINE” 6-Mercaptopurine Chemical structure Chemically 6-Mercaptopurine is analog of adenine and hypoxanthine Mechanism of action 6-Mercaptupurine is converted to 6- Mercaptopurine nucleosides leading to De novo inhibition of purine nucleotide synthesis. ¨ 6-Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine/guanine phosphoribosyltransferase and itself converted to thioinosinic acid ...

SNORING PROBLEMS AND SOLUTION

Snoring Problems and Solutions Some people only learn about their snoring problems when another person tells them about it. Most of the time, a snorer doesn’t even know they snore. Snoring is the sound created when air cannot pass through the airway smoothly. It is caused by physical obstructions such as big tonsils and bulky throat tissues. But how can one get rid of it? Lose Weight It is not a coincidence that around 50% of all American adults snore and that 30% of them are overweight. Being overweight is a primary cause of snoring. Bulky or fatty throat tissues, along with poorly toned throat muscles, will easily fall back into the throat to create snoring sounds. Being overweight means more fats around the throat. Poorly toned throat muscles, on the other hand, are caused by lack of exercise. Since no specific exercise is designed to lessen fats around the area, a full-body exercise will have to do. Frequent and regular exercising may also help with the weight loss,...

ANATOMY OF NEUROTRANSMITTERS

Anatomy of neurotransmitters An understanding of the synaptic transmission is of great importance in understanding the basic principle of chemical signaling between the neurons. This chemical process of interaction or signaling between the neurons occurs at the end of the axon, in a structure called synapse. Synapse: As neurons form a network, so they have to be interconnected for the purpose of transmission of nerve impulse from one neuron to the other. But, unlike other cells there is a lack of a cellular continuity between two neurons, as they have a space between them called as the synapse. The mechanism of chemical signaling involves the release of a chemical, called a neurotransmitter from a presynaptic neuron, which further binds to the receptors which are located in the postsynaptic neuron. These neurotransmitters then act on their particular receptors and produce a particular response. Neurotransmitters: Neurotransmitters are defined as endogenous chemicals i...

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