healthconcerns

Healthconcerns “Articles on cancer” is going to add a complete pharmacology and the medicinal chemistry of the Anti-cancer drugs. So here is the first one as “6-MERCAPTOPURINE” 6-Mercaptopurine Chemical structure Chemically 6-Mercaptopurine is analog of adenine and hypoxanthine                                                  Mechanism of action 6-Mercaptupurine is converted to   6- Mercaptopurine nucleosides leading to De novo inhibition of purine nucleotide synthesis. ¨       6-Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine/guanine phosphoribosyltransferase  and itself converted to thioinosinic acid                                                                      Inosinic acid (I) MP                                                                                  Thioinosinic acid (I MP)   ¨       TIMP inhibits several reactions involving inosinic mono phosphate (IMP) including its convers